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Web-based Interspecies Correlation Estimation (Web-ICE) for Acute Toxicity: User Manual Version 3.1
Citation:
RAIMONDO, S., D. VIVIAN, AND M. G. BARRON. Web-based Interspecies Correlation Estimation (Web-ICE) for Acute Toxicity: User Manual Version 3.1. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-10/004, 2010.
Impact/Purpose:
User manual for Web-ICE internet application, version 3.1
Description:
Predictive toxicological models are integral to ecological risk assessment because data for most species are limited. Web-based Interspecies Correlation Estimation (Web-ICE) models are least square regressions that predict acute toxicity (LC50/LD50) of a chemical to a species, genus, or family based on estimates of relative sensitivity between the taxon of interest and that of a surrogate species. Web-ICE 3.0 includes a total 1440 models for aquatic taxa and 852 models for wildlife taxa. For aquatic species within the same family, Web-ICE models predict within 5-fold and 10-fold of the actual value with 91 and 96% certainty, respectively. For two species within the same order, aquatic models predict within 5-fold and 10-fold of the actual value with 86 and 96% certainty, respectively. Overall for wildlife species, Web-ICE predicts toxicity within 5-fold of the actual value with 85% certainty and within 10-fold of the actual value with 95% certainty. Models predict within 5-fold and 10-fold of the actual value with 90 and 97% certainty for wildlife surrogate and predicted taxa within the same order. For both aquatic and wildlife taxa, model certainty increases with decreasing taxonomic distance. Web-ICE 3.0 improves on earlier versions with the inclusion of an endangered species module, improved functionality of the SSD module, and more rigorous standardization of toxicity data.