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MSW Time to Tumor Model and Supporting Documentation
In Jul 2023, EPA announced the release of an R-based plotting tool, gofplot_msw() (version 1.0), and user manual in support of the EPA version of the multistage Weibull Time-to-tumor model. The accompanying user manual includes installation steps and instructions on using the tool for plotting and analysis.
Citation:
U.S. EPA. MSW Time to Tumor Model and Supporting Documentation. U.S. Environmental Protection Agency, Washington, DC, 2009.
Impact/Purpose:
The “MSW” program described in this manual was developed by Battelle Memorial Institute1 for the U.S. Environmental Protection Agency2 (“EPA”) during 2006-2009 (under EPA contract EP-C-04-027). Minor changes may have been made by EPA subsequently (as noted in source code comments). The MSW program and associated documentation are available at EPA’s BMDS web site.3 MSW was compiled using the GNU GCC compiler provided with MinGW5.0.
Description:
The multistage Weibull (MSW) time-to-tumor model and related documentation were developed principally (but not exclusively) for conducting time-to-tumor analyses to support risk assessments under the IRIS program. These programs and related documentation are made available publicly to insure that the methods and calculations used for such analyses are transparent and reproducible.
URLs/Downloads:
MSW time-to-tumor model executable, user manual, spreadsheet data template, and sample data and output files.MSW time-to-tumor model technical documentation files.
MSW time-to-tumor model peer review comments and EPA's response (PDF, 16 pp, 202 KB, about PDF)