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FASTER SCIENCE FOR BETTER DECISIONS: CHARACTERIZING ENVIRONMENTAL CONTAMINANT RISK FROM HIGH THROUGHPUT DATA
Citation:
DIX, D. J. FASTER SCIENCE FOR BETTER DECISIONS: CHARACTERIZING ENVIRONMENTAL CONTAMINANT RISK FROM HIGH THROUGHPUT DATA. Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.
Impact/Purpose:
ToxCast project
Description:
Tens of thousands of chemicals and other man-made contaminants exist in our environment, but only a fraction of these have been characterized for their potential risk to humans and there is widespread interest in closing this data gap in order to better manage contaminant risk. Current practice of exposure estimation, toxicity testing and risk characterization for environmental contaminants is too slow to support high quality science-based regulatory decisions for thousands of contaminants. This session addresses the various components required for performing rapid, quantitative and high-quality risk characterizations on thousands of contaminants. Approaches and technologies well suited to address specific aspects of this process include high throughput hazard assessments addressing the complex biology associated with environmental toxicity; using reverse dosimetry, pharmacokinetics and biomonitoring equivalents to account for dose and exposure in evaluating high throughput screening results; defining and quantifying the uncertainty associated with high throughput data; and finally, breaking from the current paradigm and using high throughput chemical risk characterization for screening, prioritization and other regulatory applications. This abstract was reviewed by EPA and approved for publication, but may not necessarily reflect official Agency policy.
URLs/Downloads:
Faster Science for Better Decisions: Characterizing Environmental Contaminant Risk from High Throughput Data (slides) (PDF, NA pp, 90 KB, about PDF)FASTER SCIENCE FOR BETTER DECISIONS: CHARACTERIZING ENVIRONMENTAL CONTAMINANT RISK FROM HIGH THROUGHPUT DATA (abs) (PDF, NA pp, 7 KB, about PDF)