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Recommendations for Developing Alternative Test Methods for Developmental Neurotoxicity
Citation:
CROFTON, K. M., L. Buzanska, S. Coecke, H. Knaut, P. Lein, W. R. MUNDY, A. Price, A. Seiler, AND A. Goldberg. Recommendations for Developing Alternative Test Methods for Developmental Neurotoxicity. Presented at Society of Toxicoloty 49th Annual meeting, Salt Lake City, UT, March 07 - 11, 2010.
Impact/Purpose:
An international group of experts developed a set of recommendations to facilitate development of alternative DNT test methods. The intent of the document is to engage the research community in the development of in vitro and alternative DNT methods, to stimulate discussion and to facilitate comparative evaluations of candidate models.
Description:
There is great interest in developing alternative methods for developmental neurotoxicity testing (DNT) that are cost-efficient, use fewer animals and are based on current scientific knowledge of the developing nervous system. Alternative methods will require demonstration of their predictive ability as well as the development and acceptance of a strategy for data interpretation. Therefore, an ·international group of experts developed a set of recommendations to facilitate development of alternative DNT test methods. The intent of the document is to engage the research community in the development of in vitro and alternative DNT methods, to stimulate discussion and to facilitate comparative evaluations of candidate models. Definitions for endpoint, test system and test method were adopted from previously published GECD guidance documents. Fourteen criteria deemed important for DNT test method development are proposed to address issues of relevance to human neurodevelopment, specificity, sensitivity and comparison of data within and between laboratories. These criteria are applicable to new approaches and are meant to stimulate input of new scientific knowledge into the development of alternative DNT methods. This abstract does not necessarily reflect the policy of the US EPA orNIEHS.