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Vascular function in diabetic individuals in association with particulate matter
Citation:
Schneider, A., T. Siponen, R. Hampel, S. Breitner, U. Kraus, L. M. NEAS, M. HERBST, A. Hinderliter, W. Cascio, A. Peters, AND R. B. DEVLIN. Vascular function in diabetic individuals in association with particulate matter. Presented at American Thoracic Society 2010 Conference, New Orleans, LA, May 14 - 19, 2010.
Impact/Purpose:
The purpose of this study was to analyze the short-term effects of air pollution on vascular function in two panels consisting of individuals with type-2 diabetes.
Description:
Rationale: Exposure to ambient air pollution has been shown to be associated with cardiovascular effects, especially in people with chronic diseases such as diabetes. The purpose of this study was to analyze the short-term effects of air pollution on vascular function in two panels consisting of individuals with type-2 diabetes. Methods: A prospective panel study with 4 repeated measurements was conducted on 22 participants in Chapel Hill, NC between Nov 2004 and Dec 2005. Daily measurements of PM2s and meteorological data were acquired on the rooftop of the exam site. A further panel study with similar design was conducted on 33 participants in Augsburg, Germany . for the period Mar 2007 to Dec 2008. Hourly measurements of air pollution and meteorology were performed at a central measurement site. In both panels, blood pressure measurements and measurements of endothelial function were conducted. Data were analyzed using mixed models with random patient effects adjusting for trend, day of the week and meteorology. Results: In the Chapel Hill panel, systolic blood pressure (BPsys) showed an immediate slight decrease (percent change: -2.7%; 95%-confidence interval: [-5.5%; 0.1%)) and together with diastolic blood pressure (BPdia) an increase with a delay of four days (BPsys: 2.6% [0.0%; 5.3%); BPdia: 2.6% [0.2%; 5.0%)) in association with ambient PM2.5. In the Augsburg panel, BPsys also suggested an immediate decrease (-2.4% [5.4%; 0.5%)); however, only BPdia decreased significantly within the first 24 hours in association with PM2 5 (-3.1% [-5.7%; -0.6%)). A comparative analysis of endothelial function measurements in both panels is ongoing. Conclusions: The data demonstrate an immediate as well as a delayed association between air pollution exposure and blood pressure in diabetic individuals. These findings add to the discussion on blood pressure effects induced by air pollution and to the concept of susceptibility due to underlying chronic diseases. This abstract of a proposed presentation does not necessarily represent EPA policy