You are here:
Assessing the effects of exposure timing on biomarker expression using 17beta-estradiol
Citation:
Hyndman, K. M., A. D. BIALES, S. E. Bartell, AND H. L. Schoenfuss. Assessing the effects of exposure timing on biomarker expression using 17beta-estradiol. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 96(4):264-272, (2010).
Impact/Purpose:
This study indicates that a broad suite of endpoints is necessary to fully assess the biological consequences of fish exposure to estrogens and that for at least field studies, a combination of vitellogenin mRNA and plasma vitellogenin analysis are most promising in deciphering exposure histories of wild caught and caged fishes.
Description:
Temporal and spatial variability in estrogenicity has been documented for many treated wastewater effluents with the consequences of this variability on the expression of biomarkers of endocrine disruption being largely unknown. Laboratory exposure studies usually utilize constant exposure concentrations which may produce biological effects that differ from those observed in organisms exposed in natural environments. In this study we investigated the effects of differential timing of exposures with 17B-estradiol (E2) on a range of fathead minnow biomarkers to simulate diverse environmentally relevant exposure profiles.