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Systems Biology and Mode of Action Based Risk Assessment (BioIT)
Citation:
EDWARDS, S. W. Systems Biology and Mode of Action Based Risk Assessment (BioIT). Presented at BioIT world conference and expo, Boston, MA, April 20 - 22, 2010.
Impact/Purpose:
The audience will gain an appreciation for the need of systems biology in environmental risk assessment. In addition, the subtle distinction between systems biology in this context vs. drug discovery will also be discussed.
Description:
The application of systems biology for risk assessment of environmental chemicals is a natural extension of its use in pharmaceutical research. The basis for this is the concept of a key event network that builds on existing mode of action frameworks for risk assessment. The application of molecular networks derived from gene expression data for prediction of susceptible subpopulations of asthmatics and for charicterization of disruption of they hypothalamic-pituitary-gonadal axis in fish will be presented.