EPA Science Inventory

Reverse Engineering Adverse Outcome Pathways in Ecotoxicology

Citation:

Perkins, E., K. Chipman, S. W. EDWARDS, T. Habib, F. Falciani, R. Taylor, G. Van Aggelen, C. Vulpe, AND P. Antczak. Reverse Engineering Adverse Outcome Pathways in Ecotoxicology. RISK ANALYSIS. Blackwell Publishing, Malden, MA, 30(1):22-38, (2011).

Description:

The toxicological effects of many stressors are mediated through unknown, or incompletely characterized, mechanisms of action. We describe the application of reverse engineering complex interaction networks from high dimensional omics data (gene, protein, meabolic, signaling) to characterize adverse outcome pathways for chemicals that disrupt the hypothalamus-pituitary-gonadal endocrine axis in fathead minnows.

Purpose/Objective:

We identify the unique challenges facing the application of this approach in ecotoxicology, and attempt to provide a road map for the utilization of these tools.

URLs/Downloads:

EDWARDS SRA.PDF   (PDF,NA pp, 67 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 01/01/2011
Completion Date: 01/01/2011
Record Last Revised: 01/15/2014
Record Created: 09/08/2009
Record Released: 09/08/2009
OMB Category: Other
Record ID: 213506

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

IMMEDIATE OFFICE

ASSOCIATE DIRECTOR FOR HEALTH