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Revisiting the Meerwein-Ponndorf-Verley Reduction: A Sustainable Protocol for Transfer Hydrogenation of Aldehydes and Ketones
Citation:
Polshettiwar, V. AND R. S. VARMA. Revisiting the Meerwein-Ponndorf-Verley Reduction: A Sustainable Protocol for Transfer Hydrogenation of Aldehydes and Ketones. GREEN CHEMISTRY. Royal Society of Chemistry, Cambridge, Uk, 11(9):1313-1316, (2009).
Impact/Purpose:
To inform the public
Description:
The metal-catalyzed transfer hydrogenation of carbonyl compounds has received much interest because of the immense number of opportunities that exist to prepare high-value products. This reaction is featured in numerous multi-step organic syntheses and is arguably the most important catalytic reaction for the synthesis of many fine and bulk chemicals. Indeed, in the last two decades, there have been several hundred publications in this area. Most of these protocols are catalyzed by precious metals and organometallic compounds. Catalyst activity is extensively influenced by the metal as well as ligands and, because of their high activity and wide applicability, a large percentage of known catalysts is based on precious metals such as palladium, rhodium, ruthenium, iridium and recently gold. However, due to the expensive cost, inadequate accessibility, and toxicity of these regularly used metals, there is an urgent need to develop less expensive and easily available catalyst systems for sustainable hydrogenation protocols.
URLs/Downloads:
REVISITING THE MEERWEIN-PONNDORF-VERLEY REDUCTION: A SUSTAINABLE PROTOCOL FOR TRANSFER HYDROGENATION OF ALDEHYDES AND KETONES