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Inhibition of the Sodium-Iodide Symporter By Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (Final Report)
Citation:
U.S. EPA. Inhibition of the Sodium-Iodide Symporter By Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (Final Report). U.S. Environmental Protection Agency, Washington, D.C., 2009.
Impact/Purpose:
This report provides an analysis of perchlorate-mediated inhibition of the sodium-iodide symporter (NIS) in humans using published PBPK models, focusing on the degree of NIS inhibition as a function of lifestage. The models provide information that may be used to address differences in human responses to perchlorate across lifestages.
Description:
EPA announced the availability of this final report as supporting material for the Federal Register Notice: Drinking Water: Perchlorate Supplemental Request for Comments as announced in an August 19, 2009 Federal Register Notice. EPA originally released this document in draft form as supporting material for the Preliminary Regulatory Determination on Perchlorate (FR Notice) in October 2008. The document has since been revised in response to comments from independent external peer review. A copy of the PBPK model code is available. In addition, the final peer review report and a summary of external peer review comments and EPA responses are available from the draft report web page.
URLs/Downloads:
PERCHLORATE_FINAL.PDF (PDF, 86 pp, 921 KB, about PDF)Perchlorate: Questions and Answers
Fact Sheet: Perchlorate Supplemental Request for Comments (PDF, 2 pp, 43 KB, about PDF)
Perchlorate Regulatory Determination
FR Notice: Aug 19, 2009
Press Release: Aug 5, 2009