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Chemical activation by mechanochemical mixing, microwave, and ultrasonic irradiation
Citation:
VARMA, R. S. Chemical activation by mechanochemical mixing, microwave, and ultrasonic irradiation. GREEN CHEMISTRY. Royal Society of Chemistry, Cambridge, Uk, 10(11):1129-1130, (2008).
Impact/Purpose:
To inform the public
Description:
The use of emerging MW-assisted chemistry techniques in conjunction with benign reaction media is dramatically reducing chemical waste ad reaction times in several organic syntheses and chemical transformations. This editorial comments on the recent developments in mechanochemical, MW- and Ultrasound-assisted synthesis in the context of organocatalytic reactions. Mechanochemical organocatalytic strategy has deonstrasted good stereoselectivity in asymmetric aldol reaction, Baylis-Hilman reaction, and the protection of the heterocyclic amino groups of nucleosides. On the same organocatalytic theme, MW-assisted enantioselective proline-catalyzed a-aminomethylation of ketones has successfully reduced the reaction time and catalyst loading. Several reactions, Michael addition, Baylis-Hilman, and Diels-Alder, have been some of the beneficiaries of exposure to MW and ultrasonic irradiation in terms of shortening the reaction times and reducing the amount of reagents and solvents that are often used in excess.
URLs/Downloads:
CHEMICAL ACTIVATION BY MECHANOCHEMICAL MIXING, MICROWAVE, AND ULTRASONIC IRRADIATION