You are here:
Benchmark Dose Technical Guidance Document (External Review Draft)
[2/27/07] The BMDS software (version 1.4.1) is available for download at https://www.epa.gov/bmds
Citation:
U.S. EPA. Benchmark Dose Technical Guidance Document (External Review Draft). U.S. Environmental Protection Agency, Washington, D.C., EPA/630/R-00/001, 2000.
Description:
The purpose of this document is to provide guidance for the Agency on the application of the benchmark dose approach in determining the point of departure (POD) for health effects data, whether a linear or nonlinear low dose extrapolation is used. The guidance includes discussion on computation of benchmark doses and benchmark concentrations (BMDs and BMCs) and their lower confidence limits, data requirements, dose-response analysis, and reporting requirements. This guidance is based on today's knowledge and understanding, and on experience gained in using this approach.
URLs/Downloads:
FR NOTICE: NOVEMBER 20, 2000
BMD-EXTERNAL_10_13_2000.PDF (PDF, 96 pp, 830 KB, about PDF)
CHARGE.PDF (PDF, 2 pp, 8 KB, about PDF)
LOGISTICS.PDF (PDF, 3 pp, 18 KB, about PDF)