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INDUCTION OF ALBENDAZOLE RESISTANCE IN GIARDIA LAMBLIA
Citation:
Lindquist, H. INDUCTION OF ALBENDAZOLE RESISTANCE IN GIARDIA LAMBLIA. Microbial Drug Resistance v.2(4):433-434, (1996).
Description:
Previous studies have shown that Giardia lamblia resistance to metronidazole can be induced in the laboratory, and treatment failures with this drug have also been documented. As replacement theraples, anthelmintic benzimidazoles have antigiardial activity with few clinical side
effects. Albendazole has the greatest antigiardial activity3 of anthelmintic benzimidazoles tested and is effective in vivo.5 Although Chavez et al.1 failed to subculture albendazole-exposed G. lamblia, some patient isolates have shown decreased in vitro sensitivity to this drug.6 In this study, in vitro resistance to albendazole was induced in G. lamblia by a method similar to that reported by Townson et al.8