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Determinants of Whether Or Not Mixtures of Disinfection By-Products Are Similar
Through this summary the EPA announces the availability of 6 recent publications that offer approaches for using existing toxicity data on a known mixture to assess potential health risks from exposure to another related mixture (e.g., from a similar type of treatment process or emissions source) for which adequate toxicity data are unavailable and may be difficult or expensive to generate.
Citation:
Bull, R. J., G. E. RICE, AND L. K. TEUSCHLER. Determinants of Whether Or Not Mixtures of Disinfection By-Products Are Similar. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. Taylor & Francis, Inc., Philadelphia, PA, 72(7):437-460, (2009).
Impact/Purpose:
Judgements of sufficient similarity can be extremely challenging for complex mixtures such as drinking water DBPs. The chemical disinfection of drinking water produces hundreds of DBPs through reaction of the disinfecting agent (e.g., chlorine, ozone) with the organic matter in the water, and health effects have been observed in both toxicological and epidemiological studies.
Description:
This project summary and its related publications provide information on the development of chemical, toxicological and statistical criteria for determining the sufficient similarity of complex chemical mixtures.
URLs/Downloads:
Feder, P.I., Z. Ma, R.J. Bull, J.E. Simmons, et al. 2007. Evaluating Sufficient Similarity for Drinking Water Disinfection By-Product (DBP) Mixtures with Bootstrap Hypothesis Test Procedures.
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