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An Approach to Using Toxicogenomic Data in U.S. EPA Human Health Risk Assessments: A Dibutyl Phthalate (Dbp) Case Study (External Review Draft)
EPA is announcing a 30-day public comment period for the draft document, An Approach to Using Toxicogenomic Data in U.S. EPA Human Health Risk Assessments: A Dibutyl Phthalate Case Study (External Review Draft), as announced in the May 20, 2009 Federal Register Notice. In addition EPA will convene an independent panel of experts to conduct an external peer-review workshop to review the external review draft report. The deadline for comments is June 19, 2009.
Citation:
U.S. EPA. An Approach to Using Toxicogenomic Data in U.S. EPA Human Health Risk Assessments: A Dibutyl Phthalate (Dbp) Case Study (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-09/028A, 2009.
Impact/Purpose:
This draft report is a description of an approach to evaluate genomic data for use in risk assessment and a case study to illustrate the approach. The dibutyl phthalate (DBP) case study example focuses on male reproductive developmental effects and the qualitative application of the available genomic data.
Description:
This draft report is a description of an approach to evaluate genomic data for use in risk assessment and a case study to illustrate the approach. The dibutyl phthalate (DBP) case study example focuses on male reproductive developmental effects and the qualitative application of the available genomic data. The case study presented in this draft document is a separate activity from any of the ongoing IRIS human health assessments for the phthalates.
URLs/Downloads:
An Approach to Using Toxicogenomic Data in U.S. EPA Human Health Risk Assessments: A Dibutyl Phthalate Case Study (External Review Draft) (PDF, 268 pp, 6642 KB, about PDF)Charge to External Peer Reviewers (PDF, 2 pp, 79 KB, about PDF)
Register for the Workshop
FR Notice: May 20, 2009