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Elevated ERCC-1 Gene Expression in blood cells associated with exposure to arsenic from drinking water in Inner Mongolia
Citation:
Mo, J., Z. Ning, Y. Xia, T. J. WADE, AND J. S. MUMFORD. Elevated ERCC-1 Gene Expression in blood cells associated with exposure to arsenic from drinking water in Inner Mongolia. ANTICANCER RESEARCH. International Institute of Anticancer Research, Kapandriti Attiki, Greece, 29(8):3253-3259, (2009).
Impact/Purpose:
The objective of this study was to investigate arsenic effects on a DNA nucleotide excision repair gene.
Description:
Background: Chronic arsenic exposure has been associated with human cancers. The objective of this study was to investigate arsenic effects on a DNA nucleotide excision repair gene, ERCC1, expression in human blood cells. Material and Methods: Water and toe nail samples were collected from a total of 327 Inner Mongolian residents for arsenic analysis. Blood samples were collected to determine mRNA expression levels by real-time PCR. Results: The mRNA levels of ERCC1 expression were positively associated with water arsenic concentrations (slope=0.313, p=0.0043) and nail arsenic concentration (slope=0.474, p=0.0073). mRNA levels of ERCC1 expression were significantly correlated with those of OGG1, a base pair excision repair gene, (r=0.275, p<0.0001). Conclusion: The results showed that mRNA levels of ERCC1 expression was significantly associated with water arsenic concentrations, implicating the DNA repair response induced by arsenic exposure.
