Citation:

U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (Final Report, 2010). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/005F, 2010.

Impact/Purpose:

1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture.

Description:

EPA announced the release of the final report, Toxicological Review of 1,4-Dioxane (CAS No. 123-91-1): In Support of Summary Information on the Integrated Risk Information System (IRIS). The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture.

This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.

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