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The Toxicity Data Landscape for Environmental Chemicals (journal)
Citation:
JUDSON, R., A. M. RICHARD, D. J. DIX, K. A. HOUCK, M. T. MARTIN, R. J. KAVLOCK, V. DELLARCO, T. HENRY, T. HOLDERMAN, P. SAYRE, S. TAN, T. CARPENTER, AND E. SMITH. The Toxicity Data Landscape for Environmental Chemicals (journal). ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 117(5):685-95, (2009).
Impact/Purpose:
ACToR contains chemical structure; physical-chemical properties; in vitro assay data; tabular in vivo data; summary toxicology calls (e.g. a statement that a chemical is considered to be a human carcinogen); and links to online toxicology summaries. We use data from ACToR to assess the toxicity data landscape for environmental chemicals. We show results for a set of 9,912 environmental chemicals being considered for analysis as part of the U.S. EPA ToxCastTM screening and prioritization program. These include High and Medium Production Volume chemicals (HPVs and MPVs), pesticide active and inert ingredients and drinking water contaminants. Conclusions: Approximately two-thirds of these chemicals have at least limited toxicity summaries available
Description:
Thousands of chemicals are in common use but only a portion of them have undergone significant toxicological evaluation, leading to the need to prioritize the remainder for targeted testing. To address this issue, the U.S. Environmental Protection Agency (U.S. EPA) and other organizations are developing chemical screening and prioritization programs. As part of these efforts, it is important to catalog, from widely dispersed sources, the toxicology information that is available. The main objective of this analysis is to define a list of environmental chemicals that are candidates for the U.S. EPA screening and prioritization process, and to catalog the available toxicology information. We are developing ACToR (Aggregated Computational Toxicology Resource), which combines information for hundreds of thousands of chemicals from >200 public sources including the U.S. EPA, NIH (National Institutes of Health), FDA (Food and Drug Administration), corresponding agencies in Canada, Europe and Japan, and academic sources.
