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Physiological Parameters Database for PBPK Modeling (External Review Draft)
EPA is releasing an ACCESS database file containing physiological parameter data intended to be suitable for application with PBPK modeling. This was announced in the April 16, 2009 Federal Register Notice. The public review and comment period will be for 30 days. EPA requests that interested users comment on the functionality or usability of this resource and provide comments that may be considered for improving the final product.
Impact/Purpose:
EPA is releasing a database containing values of human and animal physiological parameters for public comment. The information assembled in this database should provide a scientific basis for selection of several key physiological parameters for dosimetry modeling for application in risk assessment.
Description:
EPA released for public comment a physiological parameters database (created using Microsoft ACCESS) intended to be used in PBPK modeling. The database contains physiological parameter values for humans from early childhood through senescence. It also contains similar data for animals (primarily rodents). This information (contained in this database) was collected through extensive search and contains physiological parameter data for humans from infancy through old age, as well as data for experimental laboratory species. To date, roughly 30% of the data entries have been verified by an independent contractor as a means of quality assurance and quality control (QA/QC). Because the QA/QC process will be ongoing during the public comment period, EPA requests that end-users focus on providing feedback regarding their experience working with the database, and not try duplicating efforts to QA the database. Users are also welcome to comment on specific studies or methods employed in the studies included in the database if desired.
The PBPK Modeling Database is available for download as a compressed Microsoft ACCESS file. To open the compressed file, first save the file on your hard drive, and unzip the contents into a folder of your choosing.
URLs/Downloads:
FR Notice: Apr 16, 2009
Physiological Parameters Database (Access)
Database Field Descriptions (PDF, 6 pp, 113 KB, about PDF)
Physiological Parameters Database for Older Adults (Beta 1.1)
Database of Physiological Parameters for Early Life Rats and Mice