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Incorporating "omics" in the study of reproduction and development: Virtual Tissue Models in Developmental Toxicity Research
Citation:
Sumner, S. J. AND T. B. KNUDSEN. Incorporating "omics" in the study of reproduction and development: Virtual Tissue Models in Developmental Toxicity Research. Presented at Society of Toxicology Annual Meeting, Baltimore, MD, March 15 - 19, 2009.
Impact/Purpose:
For example, posttranslation modifications of proteins that are known to be involved in cell-cell signaling cascades for developmental pathways, the flux-balance in signaling molecules themselves, or the metabolic intermediates connecting to these pathways are important parts of our ability to understand the pathogenesis of fetal malformations. These higher-level operations can be inferred, but not directly evaluated through measurement of mRNA or DNA sequencing. In recent years, the application of proteomics in the study of reproduction and development has rapidly increased, while such studies that incorporate metabolomics approaches are at their infancy. The goal of this symposium is to summarize recent advances in genomic, proteomic, and metabolomic methodologies, demonstrate the successful use of these technologies in the study of reproduction and development, and finally illustrate how these data may be integrated by multi-scale models of dynamical systems that can serve to improve our understanding of reproductive and developmental toxicities.
Description:
In recent years, ground breaking research in genomic applications in the area of reproductive and developmental toxicology have been successful in linking changes in the expression of specific genes and their higher-level biological processes to effects induced by drugs or chemicals in developing tissues. While gene expression profiling has demonstrated ability to provide mechanistic insight into cellular mechanisms of drug and chemical-induced effects, proteomics provides advantages in areas beyond the genome.
URLs/Downloads:
Incorporating "omics" in the study of reproduction and development: Virtual Tissue Models in Developmental Toxicity Research (slide) (PDF, NA pp, 4074 KB, about PDF)Incorporating "omics" in the study of reproduction and development: Virtual Tissue Models in Developmental Toxicity Research (PDF, NA pp, 11 KB, about PDF)