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Biologically Based Dose-Response Modeling. What is the potential for accurate description of the biological linkages in the applied dose - tissue dose-health effect continuum?
Citation:
CONOLLY, R. Biologically Based Dose-Response Modeling. What is the potential for accurate description of the biological linkages in the applied dose - tissue dose-health effect continuum? Presented at Society of Toxicology Annual Meeting, Baltimore, MD, March 15 - 19, 2009.
Impact/Purpose:
Specific issues that will be addressed include 1) the state-of-the-art in dosimetry modeling, 2) strategies for computational modeling of complex intra- and intercellular signaling pathways that keep the complexity at a manageable level, and 3) use of computational modeling to integrate data collected in vitro to provide estimates of risk in vivo.
Description:
Given knowledge of exposure, the shape of the dose response curve is the key to predicting health risk, which in turn determines allowable levels of exposure and the associated economic costs of compliance.