EPA is announcing the final release of the Physiological Information Database for Physiologically-Based Pharmacokinetic (PBPK) Modeling.

Citation:

Physiological Information Database (PID) . U.S. Environmental Protection Agency, Washington, DC, 2008.

Impact/Purpose:

EPA is releasing a database containing values of human and animal physiological parameters for public comment. The information assembled in this database should provide a scientific basis for selection of several key physiological parameters for dosimetry modeling for application in risk assessment.

Description:

EPA has developed a physiological information database (created using Microsoft ACCESS) intended to be used in PBPK modeling. The database contains physiological parameter values for humans from early childhood through senescence as well as similar data for laboratory animal species (primarily rodents). The database information was collected through extensive literature search. To date, all of the data entries have been verified by an independent contractor as a means of quality assurance and quality control (QA/QC).

The PID is available for download as a compressed Microsoft ACCESS file. To open the compressed file, first save the file on your hard drive, and unzip the contents into a folder of your choosing. EPA is planning to also make this available via the HERO database in FY 2010.

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