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Mutation Spectrum Induced by Conazole Fungicides in LacI Transgenic C57BL/6 Mouse Liver.
Citation:
ROSS, J. A. Mutation Spectrum Induced by Conazole Fungicides in LacI Transgenic C57BL/6 Mouse Liver. Presented at American Association for Cancer Research (AACR), Denver, CO, April 18 - 22, 2009.
Impact/Purpose:
Conazole study of DNA sequencing on mutations recovered from propiconazole and myclobutanil-treated and concurrent untreated control mouse liver.
Description:
Conazoles are antifungal agents used in both agricultural and pharmaceutical settings. Some conazoles, including propiconazole and triadimefon, induce hepatocellular tumors in mice, while other conazoles do not. We reported in a previous study that both propiconazole and triadimefon are in vivo liver mutagens in transgenic mice, whereas myclobutanil, a nontumorigen, did not induce any change in mutant frequency. We have now completed DNA sequencing on the mutations recovered from propiconazole and myclobutanil-treated and concurrent untreated control mouse liver. The mutation spectrum recovered from mice treated with propiconazole had a somewhat higher proportion of GC to AT transitions and a lower proportion of GC to TA transversions than untreated controls or mice receiving myclobutanil. AT to CG transversions were recovered from both control and myclobutanil-treated mice, but not from the propiconazole-treated mice.