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IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Preliminary Assessment Materials, 2013)

Contact

phone: (202) 566-1676
fax: (202) 566-1749
email: hotline.iris@epa.gov
Notice:

EPA hosted an IRIS public science meeting on December 12-13, 2013, to provide an opportunity for the public to give input and participate in an open discussion regarding preliminary materials that were prepared for the IRIS chemical, tert-Butyl Alcohol (tBA), prior to the development of the draft assessment.

Citation:

U.S. EPA. IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Preliminary Assessment Materials, 2013). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-13/107, 2013.

Impact/Purpose:

EPA is undertaking a new health assessment for t-butyl alcohol (TBA) for the Integrated Risk Information System (IRIS). The outcome of this project will be a Toxicological Review and IRIS and IRIS Summary of TBA that will be entered on the IRIS database. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information to evaluate potential public health risks associated with environmental contaminants. The IRIS database is relied on for the development of risk assessments, site-specific environmental decisions, and rule making.

Description:

In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for tert-Butyl Alcohol (tBA) to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:

  • Draft literature search strategies
    • The approach for identifying studies
    • The screening process for selecting pertinent studies
    • The resulting list of pertinent studies
  • Preliminary evidence tables
    • The process for selecting studies to include in evidence tables
    • The quality of the studies in the evidence tables
The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table.

Record Details:

Record Type:DOCUMENT( IRIS ASSESSMENT)
Product Published Date:08/09/2013
Record Last Revised:03/12/2020
OMB Category:Influential
Record ID: 200307