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Endocrine Disrupting Chemicals in Fish: Developing Exposure Indicators and Predictive Models of Effects Based on Mechanism of Action
Citation:
ANKLEY, G. T., D. C. BENCIC, M. BREEN, T. W. COLLETTE, R. CONOLLY, N. Denslow, S. W. EDWARDS, D. R. EKMAN, K. M. JENSEN, J. M. LAZORCHAK, D. MARTINOVIC, D. H. MILLER, E. Perkins, E. F. Orlando, N. Garcia-Reyero, D. L. VILLENEUVE, R. WANG, AND K. Watanabe. Endocrine Disrupting Chemicals in Fish: Developing Exposure Indicators and Predictive Models of Effects Based on Mechanism of Action. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 92(3):168-178, (2009).
Impact/Purpose:
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Description:
In this paper we provide an overview and illustrative results from a large, integrated project that assesses the effects of endocrine-disrupting chemicals (EDCs) on two small fish models, the fathead minnow (Pimephales promelas) and zebrafish (Danio rerio). For this work a systems-based approach is being used to delineate toxicity pathways for 12 model EDCs with different known or hypothesized toxic MOA. The studies employ a combination of state-of-the-art genomic (transcriptomic, proteomic, metabolomic), bioinformatic and modeling approaches, in conjunction with whole animal testing protocols, to develop response linkages across biological levels of organization. This understanding forms the basis for predictive approaches for species, endpoint and chemical extrapolation. Although our project is focused specifically on EDCs in fish, we believe that the basic conceptual approach has utility for systematically assessing exposure and effects of chemicals with other MOA across a variety of biological systems.
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Endocrine Disrupting Chemicals in Fish: Developing Exposure Indicators and Predictive Models of Effects Based on Mechanism of Action