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THE DEVELOPMENT AND INTER-LABORATORY VERIFICATION OF LC-MS LIBRARIES FOR ORGANIC CHEMICALS OF ENVIRONMENTAL CONCERN
Citation:
ROSAL, C. G., L. D. BETOWSKI, J. Romano, J. Neukom, D. Wesolowski, AND L. Zintek. THE DEVELOPMENT AND INTER-LABORATORY VERIFICATION OF LC-MS LIBRARIES FOR ORGANIC CHEMICALS OF ENVIRONMENTAL CONCERN. TALANTA. Elsevier Science Ltd, New York, NY, 79:810-817, (2009).
Impact/Purpose:
Clean and Safe Water – by providing water quality research and methods development at multiple scales, utilizing landscape ecology and associated techniques
Description:
The development, verification, and comparison study between LC-MS libraries for two manufacturers’ instruments and a verified protocol are discussed. The LC-MS library protocol was verified through an inter-laboratory study that involved Federal, State, and private laboratories. The results demonstrated that the libraries are transferable between the same manufacturer’s product line, and have applicability between manufacturers. Although ion abundance ratios within mass spectra were shown to be different between the manufacturers’ instruments, the NIST search engine match probability was at 96 percent or greater for 64 out of 67 compounds evaluated.
URLs/Downloads:
THE DEVELOPMENT AND INTER-LABORATORY VERIFICATION OF LC-MS LIBRARIES FOR ORGANIC CHEMICALS OF ENVIRONMENTAL CONCERN
ROSAL 08-137 FINAL JOURNAL ARTICLE..PDF (PDF, NA pp, 460 KB, about PDF)