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Gene Expression Profiling in the Liver and Lung of Perfluorooctane Sulfonate-Exposed Mouse Fetuses: Comparison to Changes Induced by Exposure to Perfluorooctanoic Acid
Citation:
ROSEN, M. B., J. E. SCHMID, K. P. DAS, C. R. WOOD, R. ZEHR, AND C. LAU. Gene Expression Profiling in the Liver and Lung of Perfluorooctane Sulfonate-Exposed Mouse Fetuses: Comparison to Changes Induced by Exposure to Perfluorooctanoic Acid . REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 27(3-4):278-288, (2009).
Impact/Purpose:
The purpose of this study was to use global gene expression profiling to evaluate the transcriptional changes induced by PFOS in the fetal mouse liver and lung. Emphasis was placed on a comparison with results previously published by our group for PFOA (43). Our hypothesis was that differences between the two datasets would be apparent and that these differences would provide testable hypotheses to further explore the PPARα-independent mode of action associated with PFOS-induced developmental toxicity observed in rodents.
Description:
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are environmental contaminants found in the tissues of humans and wildlife. They are activators of peroxisome proliferator-activated receptor-alpha (PPARα) and exhibit hepatocarcinogenic potential in rats. PFOS and PFOA are also developmental toxicants in rodents and PFOS has been shown to induce pulmonary deficits in rat offspring. Pregnant CD-1 mice were dosed with 0, 5, or 10 mg/kg PFOS from gestation day 1-17. Transcript profiling was conducted on the fetal liver and lung. Results were contrasted to data derived from a previous PFOA study. PFOS-dependent changes were primarily related to activation of PPARα. No remarkable differences were found between PFOS and PFOA. Given that PPARα signaling is required for neonatal mortality in PFOA-treated mice but not those exposed to PFOS, the neonatal mortality observed for PFOS may reflect functional deficits related to the physical properties of the chemical rather than to transcript alterations.
