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Inhibition Of The Sodium-Iodide Symporter By Perchlorate: An Evaluation Of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (Pbpk) Modeling (External Review Draft)
[12/08] EPA released this draft report as supporting material for the Preliminary Regulatory Determination on Perchlorate (FR Notice) in October 2008. Comments from the independant external peer review are now available.
Citation:
U.S. EPA. Inhibition Of The Sodium-Iodide Symporter By Perchlorate: An Evaluation Of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (Pbpk) Modeling (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-08/106A, 2008.
Impact/Purpose:
The report was subjected to external peer review and has been released with an FRN by the Office of Water, accompanying a regulatory determination.
Description:
EPA first released this document in draft form as supporting material for the Preliminary Regulatory Determination on Perchlorate (FR Notice) in October 2008. The document has since been revised. The final report is available in response to comments from independent external peer review. A copy of the PBPK model code is available. In addition, the final peer review report and a summary of external peer review comments and EPA responses are available.
URLs/Downloads:
Inhibition of the Sodium-Iodide Symporter By Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (External Review Draft) (PDF, 68 pp, 14310 KB, about PDF)Consolidated Comments from the External Peer Review (Final) (PDF, 145 pp, 1028 KB, about PDF)
FR Notice: Nov 12, 2008
FR Notice: Oct 10, 2008
PERCHLORATE_PEER_REVIEW_FINAL.PDF (PDF, 34 pp, 288 KB, about PDF)