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Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals
Citation:
ANKLEY, G. T. Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals. Chapter 4, Endocrine Toxicology, Third Edition. Taylor and Francis, Philadelphia, PA, , 102-130, (2010).
Impact/Purpose:
The purpose of this short review is to describe fish and amphibian tests for EDCs that have been (or are being) developed by the Office of Research and Development of the USEPA.
Description:
The purpose of this short review is to describe fish and amphibian tests for EDCs that have been (or are being) developed by the Office of Research and Development of the USEPA. The initial impetus for development of these tests was to support the EPA screening and testing program for EDCs (cite EDSP chapter from this book). However, the basic assay protocols have, in many instances, been adopted for use in other regulatory efforts, including one coordinated through OECD aimed at the development of internationally-harmonized test methods for EDCs. In addition, although the tests described herein were largely developed for prospective testing of endocrine-active chemicals (EDSP chapter in this book), the assays should (or in some cases already have) prove applicable to other risk assessment settings, including the analysis of complex mixtures in the field.