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Analysis of the Sensitivity and Uncertainty in 2-Stage Clonal Growth Models for Formaldehyde with Relevance to Other Biologically-Based Dose Response (BBDR) Models
Citation:
U.S. EPA. Analysis of the Sensitivity and Uncertainty in 2-Stage Clonal Growth Models for Formaldehyde with Relevance to Other Biologically-Based Dose Response (BBDR) Models. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/R-08/103, 2008.
Impact/Purpose:
In this report, we summarize publications resulting from this research effort, discuss the significance of this work for other biologically-based dose response (BBDR) applications, and provide journal reprints of two of these publications and a Web link to the scientific journal containing the third publication.
Description:
The National Center for Environmental Assessment (NCEA) has conducted and supported research addressing uncertainties in 2-stage clonal growth models for cancer as applied to formaldehyde. In this report, we summarized publications resulting from this research effort, discussed the significance of this work for other biologically-based dose response (BBDR) applications, and provided journal reprints of two of these publications and a Web link to the scientific journal containing the third publication.
URLs/Downloads:
Analysis of the Sensitivity and Uncertainty in 2-stage Clonal Growth Models for Formaldehyde with Relevance to Other Biologically Based Dose Response (BBDR) Models (PDF, 9 pp, 47 KB, about PDF)Subramaniam, R; Chen, C; Crump, K; .et .al. (2008) Uncertainties in biologically-based modeling of formaldehyde-induced cancer risk: identification of key issues. Risk Anal 28(4):907-923. (PDF, 17 pp, 415 KB, about PDF)
Subramaniam, R; Chen, C; Crump, K; .et .al. (2007) Uncertainties in the CIIT 2-stage model for formaldehyde-induced nasal cancer in the F344 rat: a limited sensitivity analysis-I. Risk Anal 27:1237 (PDF, 18 pp, 449 KB, about PDF)
Crump, K; Chen, C; Fox, J; .et .al. (2008) Sensitivity analysis of biologically motivated model for formaldehyde-induced respiratory cancer in humans. Ann Occup Hyg 52:481-495.
Conolly RB, Miller FJ, Kimbell JS, Janszen D 2009. Formaldehyde risk assessment. Ann Occup Hyg 53: 181–184.
Crump, KS; Chen, C; Fox, JF; et al. (2009) Reply to Conolly et al. (2009) Ann Occup Hyg 53:184–189.