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Hypoxia Alters Gene Expression in the Gonads of Zebrafish (Danio rerio)
Citation:
MARTINOVIC, D., D. L. VILLENEUVE, M. D. KAHL, L. BLAKE, J. BRODIN, AND G. T. ANKLEY. Hypoxia Alters Gene Expression in the Gonads of Zebrafish (Danio rerio). AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 95(4):258-272, (2009).
Impact/Purpose:
The objectives of this study were to characterize gene expression responses to hypoxia in gonads of mature zebrafish (Danio rerio), and to start characterizing modes of action by which hypoxia could potentially alter reproduction.
Description:
Reproduction is affected by hypoxia via direct modulation of expression of steroidogenic genes, but also via multiple indirect mechanisms involved in responding to hypoxia. The concern over the expansion of hypoxic environments has led to resurfacing of interest in understanding the adverse effects of, and adaptation to, hypoxia in aquatic organisms. Fish have been a subject of many hypoxia studies, as the majority of our understanding of the role of oxygen in physiology of aquatic organisms comes from work with fish.
