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Development of a Relative Potency Factor (Rpf) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft, Suspended)
[UPDATE] EPA suspended the Polycyclic Aromatic Hydrocarbon (PAH) Mixtures assessment in fiscal year 2019. This assessment may be restarted as Agency priorities change. For more information, visit the IRIS Program Outlook (Apr 2019).
Citation:
U.S. EPA. Development of a Relative Potency Factor (Rpf) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft, Suspended). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/012A, 2010.
Impact/Purpose:
The draft Relative Potency Factor approach is not a reassessment of individual PAH carcinogenicity, but rather provides a cancer risk estimate for PAH mixtures by summing doses of component PAHs after scaling the doses (with RPFs) relative to the potency of an index PAH (i.e., benzo[a]pyrene). The cancer risk is then estimated using the dose-response curve for the index PAH.
Description:
EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of polycyclic aromatic hydrocarbon (PAH) mixtures that when finalized will appear on the Integrated Risk Information System (IRIS) database.
URLs/Downloads:
IRIS_PAH_RPF_ERD.PDF (PDF, 622 pp, 7305 KB, about PDF)Charge to External Reviewers (PDF, 5 pp, 80 KB, about PDF)
SAB Project Page for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures Review Panel
SAB Review of EPA's
Draft (9/08/10) SAB Review of EPA's "Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures"
FR Notice: Feb 26, 2010
