Description:

MENTOR-2E uses an integrated, mechanistically consistent source-to-dose-to-response modeling framework to quantify inhalation exposure and doses resulting from emergency events. It is an implementation of the MENTOR system that is focused towards modeling of the impacts of releases of chemical and biological agents. MENTOR-2E uses, as one of the options, the USEPA’s Stochastic Human Exposure and Dose Simulation (SHEDS) approach.

MENTOR-2E calculates exposure and dose profiles, while providing the ability to focus on mechanism-relevant time scales, specific administrative areas, and subpopulations of interest. This is achieved by combining information on release characteristics, demographic characteristics of the population that can be potentially impacted, indoor/outdoor air exchange rates, time-activity diaries, and biologically based dosimetry. It uses the two dimensional Monte-Carlo methodology to quantify variability and uncertainty in model inputs and outputs.

MENTOR-2E has been applied to date to simulate potential casualties resulting from hypothetical releases of anthrax. It has also been applied for studying secondary exposures in hospital emergency rooms.

Plans for Future Model Development

Record Details:

Record Type:MODEL

Record Released:06/10/2008

Record Last Revised:07/11/2011

Record ID: 193583

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Model Detail:

Model Evaluation :MENTOR-2E has been applied to study the impact of hypothetical releases of anthrax for the States of Delaware and New Jersey. The results were compared with those from other approaches and the output uncertainties resulting from a subset of uncertainties were characterized.

Peer reviewed journal publications and technical reports presenting the application of MENTOR-1A are available.

Model URL :http://www.ccl.rutgers.edu/mentor/

Model Guidance Documents :Not currently available; technical documents on the formulation and applications of MENTOR-2E are available at http://www.ccl.rutgers.edu/mentor/.

Model Decision Documents :Selected publications describing the system and applications: Isukapalli, S.S., Georgopoulos, P.G., and Lioy, P.J. (2007). Mechanistic Modeling of Impacts of Emergency Events: Assessing Impact of Hypothetical Releases of Anthrax. Submitted for Publication.

Stenchikov G., Lahoti N., Diner D., Kahn R., Lioy P. and Georgopoulos P. (2006). Multiscale plume transport from the collapse of the World Trade Center on September 11, 2001. Environmental Fluid Mechanics 6(5): 425-450

Georgopoulos P.G. and Lioy P.J. (2006). From theoretical aspects of human exposure and dose assessment to computational model implementation: The modeling environment for total risk studies (MENTOR). Journal of Toxicology and Environmental Health - Part B, Critical Reviews 9(6): 457-483.

Model Download Information :This model can be downloaded here

modelcontactinfo :EPA Contact:
Dan Vallero
USEPA, NERL
Vallero.Daniel@epamail.epa.gov
919-541-3306

Developer Contacts:
Dr. Panos Georgopoulos
panosg@fidelio.rutgers.edu
732-445-0159

Dr. Sastry Isukapalli
sastry@fidelio.rutgers.edu
732-445-0171

Dr. Paul Lioy
plioy@eohsi.rutgers.edu
732-445-0393

Computational Chemodynamics Laboratory
(www.ccl.rutgers.edu), EOHSI, a joint Institute of UMDNJ – R.W. Johnson Medical School and Rutgers University, 170 Frelinghuysen Rd., Piscataway, NJ 08854.

Model Inputs :Primary or secondary source characteristics (e.g. magnitude, location, and time-profile of sources), or concentration profiles (e.g. those obtained through atmospheric dispersion models)

Model Outputs :Potential casualties, statistical measures of exposures and doses, etc.

otheruserdocs :Selected publications describing the system and applications:

Georgopoulos P.G. and Lioy P.J. (2006). From theoretical aspects of human exposure and dose assessment to computational model implementation: The modeling environment for total risk studies (MENTOR). Journal of Toxicology and Environmental Health - Part B, Critical Reviews 9(6): 457-483.

Stenchikov G., Lahoti N., Diner D., Kahn R., Lioy P. and Georgopoulos P. (2006). Multiscale plume transport from the collapse of the World Trade Center on September 11, 2001. Environmental Fluid Mechanics 6(5): 425-450

Lioy P.J., Vallero D., Foley G., Georgopoulos P., Heiser J., Watson T., Reynolds M., Daloia J., Tong S. and Isukapalli S. (2007). A personal exposure study employing scripted activities and paths in conjunction with atmospheric releases of perfluorocarbon tracers in Manhattan, New York. Journal of Exposure Science and Environmental Epidemiology 17(5): 409-425

Georgopoulos P. (2008). A multiscale approach for assessing the interactions of environmental and biological systems in a holistic health risk assessment framework. Water, Air, and Soil Pollution: Focus 8(1): 3-21

Isukapalli S.S., Lioy P.J. and Georgopoulos P.G. (2008). Mechanistic modeling of emergency events: Assessing the impact of hypothetical releases of Anthrax. Risk Analysis 28(3): 723-740.

Laumbach R., Harris G., Kipen H., Georgopoulos P., Shade P., Efstathiou C., Isukapalli S., Galea S., Vlahov D. and Wartenberg D. (2009 – in press). Respiratory symptoms are not associated with estimated WTC plume intensity and respiratory symptoms among residents outside of lower Manhattan. American Journal of Epidemiology

Model Computer Requirements:

Model Operating Systems Needs :Any of the following: Windows 2000/XP/Vista, Linux, Solaris, Mac OS X.

Model Hardware Needs :Operational on multiple, alternative hardware platforms: Intel/AMD based PCs, Sun Workstations (e.g. Sparc), Linux servers or clusters, and Apple Macintosh computers. Minimum requirements: 10 GB free hard drive space, 512 MB RAM, and 500 MHz processor.

other_req :Matlab version 6.5 or higher for Windows/Linux/Solaris/Mac OS X (Matlab statistical toolbox needed). Local or remote installation of Access or MySQL databases are needed. Depending on the application, SAS 8.0, C, or Fortran compilers may be needed. ArcGIS 8 is required for visualization.