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IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (External Review Draft)
EPA announces the release of the National Research Council's Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene in a February 9, 2010 NAS Press Release.
Citation:
U.S. EPA. IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/011A, 2008.
Impact/Purpose:
Tetrachloroethylene is a chemical solvent that is widely used for dry cleaning of fabrics, metal degreasing, and in making some consumer products and other chemicals.
Description:
EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of tetrachloroethylene that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the toxicological characterization and dose-response assessments.
This draft health assessment addresses both non-cancer and cancer human health effects that may result from chronic exposure to tetrachloroethylene (also called Perchloroethylene or Perc) . This is an update of an existing assessment posted on IRIS in 1988. This draft Toxicological Review includes a chronic Reference Concentration (RfC) and carcinogenicity assessment, which are not currently available on IRIS, as well as an update of the 1988 IRIS Reference Dose (RfD).
URLs/Downloads:
Toxicological Review of Tetrachloroethylene (Perchloroethylene) (External Review Draft) (PDF, 556 pp, 3978 KB, about PDF)Revised Charge to External Peer Reviewers (PDF, 5 pp, 48 KB, about PDF)
NRC, BEST. Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene (Final Report) 2010.
NRC, BEST. Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene (Final Report) 2010.
National Academy of Sciences related review project webpage
FR Notice: Oct 29, 2008 - Correction
FR Notice: Oct 16, 2008
FR Notice: Jul 29, 2008
FR Notice: Jun 26, 2008
AGENCY RESPONSE TO COMMENTS INCLUDED IN APPENDIX A OF THE FINAL REPORT (PDF, 1077 pp, 1443 KB, about PDF)
AGENCY RESPONSE TO COMMENTS INCLUDED IN APPENDIX A OF THE FINAL REPORT (PDF, 1077 pp, 1443 KB, about PDF)
Peer Review Plan (PDF, NA pp, 33 KB, about PDF)