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Types and Consequences of DNA Damage
Citation:
SHAUGHNESSY, D. AND D. M. DEMARINI. Types and Consequences of DNA Damage. Chapter 2, S. Knasmueller, D.M. DeMarini, I.T. Johnson, and C. Gerhauser (ed.), Chemoprevention of Cancer and DNA Damage by Dietary Factors. John Wiley & Sons Incorporated, New York, NY, , 21-33, (2009).
Impact/Purpose:
This review was done to provide an overview of how the cell deals with DNA damage and the consequences of those processes, which can be either repaired DNA, mutant DNA, or cell death. An overview of DNA damage, DNA sensing, DNA repair, and mutagenesis was considered essential to begin a book about dietary factors that may alter how the cell deals with DNA damage. Thus, this review was written to provide the necessary background information for the reader to understand the rest of the book.
Description:
This review provides a concise overview of the types of DNA damage and the molecular mechanisms by which a cell senses DNA damage, repairs the damage, converts the damage into a mutation, or dies as a consequence of unrepaired DNA damage. Such information is important in considering the mode-of-action of genotoxic carcinogens and the risk assessment process.