You are here:
Greener and Rapid Access to Bio-Active Heterocycles
Citation:
Polshettiwar, V. AND R. S. VARMA. Greener and Rapid Access to Bio-Active Heterocycles. Presented at 12th Annual Green Chemistry & Engineering Conference, Washington, DC, June 24 - 28, 2008.
Impact/Purpose:
To inform the public.
Description:
A new kind of chemical revolution “GREEN CHEMISTRY” is brewing, 150 years after the first one transformed modern life with a host of conveniences. It protects the environment, not by cleaning up, but by inventing new chemistry and new chemical processes that do not pollute. The fundamental idea of green chemistry is that the manufacturer of a chemical is responsible for considering what will happen to the human life after the chemical is put in their society. Environmentally benign protocols have been developed for the synthesis of various bio-active heterocycles namely 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,3-dioxanes, pyrazoles, hydrazones and 3,4-dihydropyrimidin-2(1H)-ones, which proceed under the influence of microwave irradiation and using eco-friendly conditions. These high-yielding greener protocols were catalyzed efficiently by solid supported Nafion®NR50, phosphorus pentasulfide on alumina (P4S10/Al2O3) under solvent-free conditions and polystyrene sulfonic acid (PSSA) in aqueous media.