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EPA's Toxcast ™ Program for Predicting Hazard and Priortizing Toxicity Testing of Environemntal Chemicals (T)
Citation:
KAVLOCK, R. J. EPA's Toxcast ™ Program for Predicting Hazard and Priortizing Toxicity Testing of Environemntal Chemicals (T). Presented at Oganisation for economic co-operation and development initial assessment meeting, Helsinki, NETHERLANDS, October 17 - 19, 2007.
Impact/Purpose:
The ToxCast program will evaluate chemical properties and bioactivity profiles across a broad spectrum of data domains: physical-chemical, predicted biological activities based on existing structure-activity models, biochemical properties based on HTS assays, cell-based phenotypic assays, and genomic analyses of cells. These data will be generated through a series of external contracts, and through collaborations within EPA, with the National Toxicology Program, and the National Institutes of Health Chemical Genomics Center. The resulting multidimensional dataset requires appropriate computational methods for integrating various chemical, biological and toxicological data into profiles and models predicting toxicity.
Description:
EPA is developing methods for utilizing computational chemistry, high-throughput screening (HTS) and various toxicogenomic technologies to predict potential for toxicity and prioritize limited testing resources towards chemicals that likely represent the greatest hazard to human health and the environment.