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One-Month Diesel Exhaust Inhalation Produces Hypertensive Gene Expression Phenotype in Healthy Rats
Citation:
Gottipolu, R. R., G. WALLENBORN, E. KAROLY, M. SCHLADWEILER, A. D. LEDBETTER, Q. T. KRANTZ, W. P. LINAK, A. Nyska, J. A. Johnson, R. THOMAS, J. E. RICHARDS, R. H. JASKOT, AND U. P. KODAVANTI. One-Month Diesel Exhaust Inhalation Produces Hypertensive Gene Expression Phenotype in Healthy Rats . ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 117(1):38-46, (2009).
Impact/Purpose:
This is a toxicological study conducted in rats to demonstrate the role of diesel exhaust particles in cardiac injury. Rats were exposed via whole body inhalation to freshly generated diesel particle episodically for a period of 4 weeks. Cardiac pathology, markers of mitochondrial oxidative stress and expression arrays were performed along with characterization of pulmonary and vascular response.
Description:
Exposure to diesel exhaust (DE) is linked to vasoconstriction, endothelial 26 dysfunction, and myocardial ischemia in compromised individuals. We hypothesized that DE 27 inhalation would cause greater inflammation, hematological alterations, and cardiac molecular 28 impairment in spontaneously hypertensive (SH) than healthy Wistar Kyoto (WKY) rats.
