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Comparing HPLC-ESI-ITMS and UPLC-ESI-OA-TOF-MS in Characterizing Macrolide Antibiotics and Illicit Drugs in Complex Environmental Matrices
Citation:
JONES-LEPP, T. L. Comparing HPLC-ESI-ITMS and UPLC-ESI-OA-TOF-MS in Characterizing Macrolide Antibiotics and Illicit Drugs in Complex Environmental Matrices. Presented at American Society of Mass Spectrometry, Denver, CO, June 01 - 05, 2008.
Impact/Purpose:
Presentation
Description:
Among the challenges of characterizing emerging contaminants in complex environmental matrices (e.g., biosolids, sewage, or wastewater) are the co-eluting interferences. For example, surfactants, fats, and humic acids, can be preferentially ionized instead of the analyte(s) of interest, or mask their presence. Modern analytical detection techniques such as GC- and LC-MS/MS (i.e., ion traps, triple quadrupoles, magnetic sector, and time-of- flight mass spectrometers) can be used to deconvolute the interferences from the compounds of interest. This presentation will discuss using a Varian 500 LC-MS iontrap (MS/MS mode) as a screening tool, with follow-up confirmation using a Waters LCT UPLC-TOF for assigning accurate masses to the emerging contaminants.