EPA Science Inventory

Particulate matter, oxidative stress and neurotoxicity.

Citation:

MohanKumar, S. M., A. Campbell, M. Block, AND B. VERONESI. Particulate matter, oxidative stress and neurotoxicity. NEUROTOXICOLOGY. Intox Press, Inc, Little Rock, AR, 29(3):479-488, (2008).

Description:

Particulate matter (PM), a component of air pollution has been epidemiologically associated with sudden deaths, cardiovascular and respiratory illnesses. The effects are more pronounced in patients with pre-existing conditions such as asthma, diabetes or obstructive pulmonary disorders. Clinical and experimental studies have historically focused on the cardiopulmonary effects of PM. However, since PM particles carry numerous biocontaminants that are capable of triggering free radical production and cytokine release, the possibility that PM may affect organs systems sensitive to oxidative stress must be considered. Four independent studies that summarize the neurochemical and neuropathological changes found in the brains of PM exposed animals are described here. These were recently presented at two 2007 symposia sponsored by the Society of Toxicology (Charlotte, NC) and the International Neurotoxicology Association (Monterey, CA).

Purpose/Objective:

To support criteria for MYP.

URLs/Downloads:

NEUROTOXICOLOGY   Exit

NEUROTOXICOLOGY   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Projected Completion Date: 09/01/2008
Record Last Revised: 03/26/2013
Record Created: 01/10/2008
Record Released: 01/10/2008
OMB Category: Other
Record ID: 188085

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

NEUROTOXICOLOGY DIVISION

CELLULAR AND MOLECULAR TOXICOLOGY BRANCH