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NTP-CERHR Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A
Citation:
Chapin, R. E., J. Adams, K. Boekelheide, L. E. Gray, S. W. Hayward, P. S. Lees, B. S. McIntyre, K. M. Portier, T. M. Schnorr, S. G. Selevan, J. G. Vandenbergh, AND S. R. Woskie. NTP-CERHR Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A. U.S. Department of Health & Human Services, NIEHS, Research Triangle Park, NC, 2007.
Impact/Purpose:
The Expert Panel Report on Bisphenol A is intended to (1) interpret the strength of scientific evidence that bisphenol A is a reproductive or developmental toxicant based on data from in vitro, animal, or human studies, (2) assess the extent of human exposures to include the general public, occupational groups, and other sub-populations, (3) provide objective and scientifically thorough assessments of the scientific evidence that adverse reproductive and developmental health effects may be associated with such exposures, and (4) identify knowledge gaps to help establish research and testing priorities to reduce uncertainties and increase confidence in future evaluations.
Description:
The National Toxicology Program (NTP)1 established the NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) in June 1998. The purpose of the CERHR is to provide timely, unbiased, scientifically sound evaluations of the potential for adverse effects on reproduction or development resulting from human exposures to substances in the environment. The NTP-CERHR is headquartered at NIEHS, Research Triangle Park, NC and is staffed and administered by scientists and support personnel at NIEHS. Bisphenol A is a high-production volume chemical used in the production of epoxy resins, polyester resins, polysulfone resins, polyacrylate resins, polycarbonate plastics, and flame retardants. Polycarbonate plastics are used in food and drink packaging; resins are used as lacquers to coat metal products such as food cans, bottle tops, and water supply pipes. Some polymers used in dental sealants and tooth coatings contain bisphenol A. Exposure to the general population can occur through direct contact with bisphenol A or by exposure to food or drink that has been in contact with a material containing bisphenol A. CERHR selected bisphenol A for evaluation because of (1) high production volume, (2) widespread human exposure, (3) evidence of reproductive toxicity in laboratory animal studies, and (4) public concern for possible health effects from human exposures. Relevant literature on bisphenol A was identified from searches of the PubMed (Medline) and Toxline databases through February 2007 using the term “bisphenol” and the bisphenol A CAS RN (80-05-7). References were also identified from databases such as REPROTOX®, HSDB, IRIS, and DART, from the bibliographies of the literature reviewed, by members of the expert panel, and in public comments.
URLs/Downloads:
NTP-CERHR Expert Panel Report on the Reproductive andDevelopmental Toxicity of Bisphenol A