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IRIS Toxicological Review of Acrylamide (External Review Draft)
In December 2007, EPA released the draft report,Toxicological Review for Acrylamide, for public comment and external peer review (step 5 of the IRIS Assessment Development Process. EPA's Science Advisory Board (SAB) conducted the peer review which was previously announced in a February 1, 2008 Federal Register Notice. Subsequent to the SAB review, an external letter peer consultation of methodology used to derive the internal dose was conducted. The report from this review is now available.
Citation:
U.S. EPA. IRIS Toxicological Review of Acrylamide (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-07/009A.
Impact/Purpose:
The draft Toxicological Review of Acrylamide provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to a chronic exposure to acrylamide.
Description:
EPA has conducted a peer review by EPA’s Science Advisory Board (SAB) of the scientific basis supporting the human health hazard and dose-response assessment of acrylamide that once finalized will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that the science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
URLs/Downloads:
FR Notice: Feb 1, 2008
FR Notice: Dec 28, 2007
Toxicological Review of Acrylamide (CAS No. 79-06-1) In Support of Summary Information on the Integrated Risk Information System (IRIS) External Review Draft (PDF, 377 pp, 1556 KB, about PDF)
Consolidated Comments from the External Peer Review (Final) (PDF, 30 pp, 207 KB, about PDF)
AGENCY RESPONSE