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MICROWAVE-ASSISTED GREENER SYNTHESIS OF PHARMACEUTICALLY ACTIVE HETEROCYCLES UNDER BENIGN CONDITIONS
Citation:
VARMA, R. S. AND V. Polshettiwar. MICROWAVE-ASSISTED GREENER SYNTHESIS OF PHARMACEUTICALLY ACTIVE HETEROCYCLES UNDER BENIGN CONDITIONS. Presented at 235th American Chemical Society National Meeting, New Orleans, LA, April 06 - 10, 2008.
Impact/Purpose:
To inform the public.
Description:
Green chemistry is a rapidly developing new field that provides us a proactive avenue for the sustainable development of future science and technologies. Environmentally benign protocols have been developed for the synthesis of various pharmaceutically active heterocycles namely 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,3-dioxanes, pyrazoles, hydrazones and 3,4-dihydropyrimidin-2(1H)-ones, which proceed under the influence of microwave irradiation and using eco-friendly conditions. These high-yielding greener protocols were catalyzed efficiently by solid supported Nafion®NR50, phosphorus pentasulfide on alumina (P4S10/Al2O3) under solvent-free conditions and polystyrene sulfonic acid (PSSA) in aqueous media.