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IRIS Toxicological Review and Summary Documents for Boron
Impact/Purpose:
The purpose of this activity is to develop an updated Agency assessment of the health effects and risks associated with Boron including an updated IRIS Toxicological Review and summary sheets.
Description:
Boron was last updated on IRIS in the late 1980's . Since that time new studies have provided developmental data in three species. The goal of this updated IRIS file is to re-assess the RfD based on new research and updated methodology, specifically application of the benchmark approach for estimating dose-response. This approach allows for the incorporation of all appropriate dose response data rather than a single data set from one study. Additional data were developed to address issues concerning boron toxicokinetics. Pharmacokinetic studies on the clearance of boron in rats and humans have been completed and incorporated into the Toxicological Review. Data from these studies are being used to determine uncertainty factors in the calculation of the boron RfD. This new assessment will provide a better understanding of the pharmacokinetic interspecies and intraspecies extrapolation associated with boron risk assessment and will aid in making informed risk based decisions for protection of human health.