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Modeling the Pharmacokinetics of Perfluorooctanoic Acid (PFOA) During Gestation and Lactation in Mice
Citation:
RODRIGUEZ, C. E. AND H. A. BARTON. Modeling the Pharmacokinetics of Perfluorooctanoic Acid (PFOA) During Gestation and Lactation in Mice. Presented at Society of Toxicology Annual Meeting, Seattle, WA, March 16 - 20, 2008.
Impact/Purpose:
These modeling efforts provide an initial template for further explorations of the pharmacokinetics of PFOA relevant to one-generation toxicity studies.
Description:
To address the pharmacokinetics of PFOA during gestation and lactation, a biologically supported dynamic model was developed. A two compartment system linked via placental blood flow described gestation, while milk production linked the dam to a pup litter compartment during lactation. Mathematical functions described the growth of the dam, conceptus, placental blood flow, and nursing pups. Maternal serum: milk and serum: fetal partition coefficients and milk production were estimated from published literature. Absorption and elimination were described as first order processes.
URLs/Downloads:
Modeling the Pharmacokinetics of Perfluorooctanoic Acid (PFOA) During Gestation and Lactation in Mice (PDF, NA pp, 17 KB, about PDF)Modeling the Pharmacokinetics of Perfluorooctanoic Acid (PFOA) During Gestation and Lactationin Mice Poster (PDF, NA pp, 177 KB, about PDF)