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ToxRefDB: Classifying ToxCast™ Phase I Chemicals Utilizing Structured Toxicity Information
Citation:
MARTIN, MATT, R. JUDSON, A. M. RICHARD, K. A. HOUCK, AND D. J. DIX. ToxRefDB: Classifying ToxCast™ Phase I Chemicals Utilizing Structured Toxicity Information. Presented at Society of Toxicology Annual Meeting, Seattle, WA, March 16 - 20, 2008.
Impact/Purpose:
ToxRefDB will provide the essential interpretive context for HTS and genomic data being generated in U.S. EPA's ToxCast chemical prioritization program.
Description:
There is an essential need for highly detailed chemicals classifications within the ToxCast™ research program. In order to develop predictive models and biological signatures utilizing high-throughput screening (HTS) and in vitro genomic data, relevant endpoints and toxicities must first be identified and globally characterized for EPA’s ToxCast Phase I chemicals (www.epa.gov/comptox/toxcast).