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TRANSCRIPTIONAL RESPONSES IN THYROID TISSUES FROM RATS TREATED WITH A TUMORIGENIC AND A NON-TUMORIGENIC TRIAZOLE CONAZOLE FUNGICIDE
Citation:
NESNOW, S. AND S. D. HESTER. TRANSCRIPTIONAL RESPONSES IN THYROID TISSUES FROM RATS TREATED WITH A TUMORIGENIC AND A NON-TUMORIGENIC TRIAZOLE CONAZOLE FUNGICIDE. Presented at American Chemical Society, 235th National Meeting and Exposition, New Orleans, LA, April 06 - 10, 2008.
Impact/Purpose:
Pathways and networks of genes that were associated with thyroid cancer were identified through microarray transcriptional analyses of thyroid tissues from rats treated with triadimefon, a tumorigenic, and myclobutanil, a non-tumorigenic conazole.
Description:
Conazoles are fungicides that are used in agriculture and medicine. Conazoles can induce follicular cell adenomas of the thyroid in rats after chronic bioassay and are considered to pose a hazard to humans. Pathways and networks of genes that were associated with thyroid cancer were identified through microarray transcriptional analyses of thyroid tissues from rats treated with triadimefon, a tumorigenic, and myclobutanil, a non-tumorigenic conazole. Gene expression was analyzed by the Gene Set Expression Analyses method which clearly separated the tumorigenic treatments from the non-tumorigenic treatments. Genes, pathways, and networks were identified as being associated with triadimefon-treated rat thyroid tissues. It is postulated that triadimefon activates the nuclear receptor, peroxisome proliferator activated receptor (PPAR)-gamma, initiating transcription of gene products, oxidative response genes, and signaling to a series of genes involved in cell proliferation. Many of these genes were mapped to human thyroid tumors.