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SODIUM BICARBONATE FACILITATES LOW-DOSE ORAL TOLERANCE TO PEANUT IN MICE
Citation:
BOWMAN, C. AND M. K. SELGRADE. SODIUM BICARBONATE FACILITATES LOW-DOSE ORAL TOLERANCE TO PEANUT IN MICE. Presented at American Academy of Allergy, Asthma, and Immunology Annual Meeting, Philadelphia, PA, March 14 - 18, 2008.
Impact/Purpose:
The current study objective was to determine the specific experimental parameters required to achieve oral tolerance to peanut.
Description:
Rationale: Oral tolerance specifically inhibits production of allergic IgE antibody and is therefore a potential method for suppressing food allergy. We have previously demonstrated that a single oral dose of one mg is sufficient to induce oral tolerance to egg white but not peanut extract in mice. The current study objective was to determine the specific experimental parameters required to achieve oral tolerance to peanut.