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BIGINELLI REACTION IN AQUEOUS MEDIUM: A GREENER AND SUSTAINABLE APPROACH TO SUBSTITUTED 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES

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Citation:

POLSHETTIWAR, V. AND R. S. VARMA. BIGINELLI REACTION IN AQUEOUS MEDIUM: A GREENER AND SUSTAINABLE APPROACH TO SUBSTITUTED 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES. B. Ganem, Lin Guo-Qiang, E.J. Thomas, J. Wood, Y. Yamamoto, S.Z. Zard (ed.), TETRAHEDRON LETTERS. Elsevier Science Ltd, New York, NY, 48(41):7343-7346, (2007).

Impact/Purpose:

Journal Article

Description:

An environmentally benign aqueous Biginelli protocol for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using polystyrenesulfonic acid (PSSA) as a catalyst has been achieved. These microwave-assisted reactions proceed efficiently in water in the absence of organic solvent, with simple filtration as the product isolation step.

Record Details:

Record Type:DOCUMENT( JOURNAL/ PEER REVIEWED JOURNAL)
Product Published Date:10/08/2007
Record Last Revised:02/07/2008
OMB Category:Other
Record ID: 182028