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ASTHMATIC HUMAN SERUM IGE-REACTIVITY WITH MOLD EXTRACTS
Citation:
WARD, M. D., Y. CHUNG, E. R. SVENDSEN, K. YEATTS, D. PEDEN, L. M. NEAS, AND R. B. DEVLIN. ASTHMATIC HUMAN SERUM IGE-REACTIVITY WITH MOLD EXTRACTS. Presented at American Academy of Asthma, Allergy, and Immunology Annual Meeting, Philadelphia, PA, March 14 - 18, 2008.
Impact/Purpose:
This study was undertaken to provide insight into the prevalence of human IgE-reactivity and identify the target mold protein(s).
Description:
Although molds have demonstrated the ability to induce allergic asthma-like responses in mouse models, their role in human disease is unclear. This study was undertaken to provide insight into the prevalence of human IgE-reactivity and identify the target mold protein(s). The study objectives were 1) to identify mold extracts that are bound by IgE in serum from human asthmatics, 2) to describe the protein profile of this reactivity and 3) to compare humans and mouse IgE-reactive protein profiles.